IDEAYA Announces Partnership With The Broad Institute And Advancement Of Synthetic Lethality Programs And Platform

IDEAYA Biosciences announced today that it has entered into a target and biomarker discovery partnership with the Sellers Laboratory at the Broad Institute of MIT and Harvard.

The IDEAYA partnership with the laboratory of William R. Sellers, M.D., Core Institute Member, Broad Institute, will utilize the CRISPR paralog screening platform developed at the Broad Institute to evaluate functionally redundant paralogous genes across ovarian cancer subtypes and to generate novel Synthetic Lethality (SL) based target and biomarker discoveries. In addition, the IDEAYA and Broad collaboration will evaluate paralog CRISPR knockdown in selected cell lines in conjunction with pharmacological inhibition of PARG to inform patient selection and combination strategies in both ovarian and breast cancer.  IDEAYA has also become a member of the DepMap (Cancer Dependency Map) consortium led by Broad Institute to further enhance IDEAYA's efforts in bioinformatics and cell-based screening for SL target and biomarker discovery and validation.

Sellers, who also serves on the IDEAYA scientific advisory board Said: "Our lab has developed large-scale screening approaches to identify and validate novel Synthetic Lethal interactions, and we look forward to collaborating with IDEAYA to translate this research for the discovery of potential patient-selection biomarkers and cancer therapeutics."  

Michael P. Dillon, Ph.D., Chief Scientific Officer, IDEAYA Biosciences Said: "We are delighted to collaborate with the Sellers Lab at the Broad Institute and leverage their molecular biology expertise and paralog CRISPR screening approach to enhance our Synthetic Lethality target and biomarker discovery efforts."

Update on IDEAYA SL Platform and Programs:

IDEAYA has constructed its DECIPHER Dual CRISPR Synthetic Lethality platform for SL target and biomarker discovery in collaboration with the University of California, San Diego, and bioinformatics analysis and preclinical validation are ongoing.  The DECIPHER 1.0 library is focused on DNA Damage Repair targets across various tumor suppressor genes and oncogenes of interest that were selected based on their known prevalence and role in solid tumors, enabling evaluation of approximately 50,000 independent gene knockout combinations of DDR pathway related drug targets across known tumor suppressor genes.

In addition to its three GSK-partnered Synthetic Lethality programs in MAT2A, Pol Theta and Werner Helicase, IDEAYA has several wholly owned SL and DNA Damage Target (DDT) programs, including PARG and multiple additional SL / DDT preclinical programs. 

The PARG program is targeting Development Candidate nomination in 2021.  Patient selection biomarker validation is ongoing for PARG, including a panel of PDX models in select tumor types and in defined genetic settings.  IDEAYA is also advancing additional preclinical SL / DDT programs that are potential first-in-class programs.

Yujiro S. Hata, President and CEO, IDEAYA Biosciences Said: "We are executing on our strategy to build the industry leading Synthetic Lethality focused biotechnology company, including through strategic partnerships.  The Broad and earlier announced GSK partnership advances our efforts to extend our research leadership in Synthetic Lethality and to build a diverse pipeline of potential first-in-class Synthetic Lethality programs."

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